Biomass-derived label-free surface enhanced Raman spectroscopy (SERS) sensor for detection of amyloid beta biomarker for early diagnosis of Alzheimer's disease by analyzing saliva, and utilizing SERS substrate, comprises substrate of biomass-derived carbon fibers decorated with silver nanoparticles
	UNNATHPADI R; FAHEEM A; VEINTRAMUTHU S; SUNIL N; PULLITHADATHIL B
	2024-12-23
专利权人	PSG ADVANCED STUDIES INST (PSGA-Non-standard)
申请日期	2024-12-23
专利号	IN202441102075-A
成果简介	NOVELTY - Biomass-derived label-free surface enhanced Raman spectroscopy (SERS) sensor comprises substrate comprising biomass-derived carbon fibers (CFs) decorated with silver nanoparticles (AgCFs). USE - Biomass-derived label-free surface enhanced Raman spectroscopy (SERS) sensor for detection of amyloid beta biomarker for early diagnosis of Alzheimer's disease through the analysis of biological samples, such as saliva, utilizing the SERS substrate (claimed). ADVANTAGE - The sensor is highly sensitive, and biocompatible, and it offers a cost-effective alternative to traditional diagnostic techniques, making it accessible for widespread clinical use, and allows for fast analysis of amyloid beta levels, enabling timely diagnosis and intervention in Alzheimer's disease management. The use of biomass-derived nanomaterials in the substrate significantly enhances sensor performance by leveraging their unique structural properties, contributing to improved SERS signal strength. The AgCFs SERS substrate is applied to a variety of biological samples, expanding its utility for diagnosing amyloid beta-related conditions beyond Alzheimer's disease. The SERS substrate is capable of detecting amyloid beta concentrations as low as 10 μM, demonstrating superior sensitivity compared to existing diagnostic methods. The substrate utilizes environmentally friendly biomass-derived materials, promote sustainability in the development of diagnostic technologies, improve Alzheimer's disease diagnostics, SERS substrate leverages the unique structural properties of biomass-derived nanomaterials to significantly enhance sensor performance. The substrate is applied for the early detection of amyloid beta (25-35), which is a critical biomarker for Alzheimer's disease.
IPC 分类号	B22F-009/24 ; B82Y-030/00 ; G01N-021/65 ; G01N-033/68 ; H01J-037/26
国家	印度
专业领域	材料科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/13850
专题	中国科学院新疆生态与地理研究所
作者单位	PSG ADVANCED STUDIES INST (PSGA-Non-standard)
推荐引用方式 GB/T 7714	UNNATHPADI R,FAHEEM A,VEINTRAMUTHU S,et al. Biomass-derived label-free surface enhanced Raman spectroscopy (SERS) sensor for detection of amyloid beta biomarker for early diagnosis of Alzheimer's disease by analyzing saliva, and utilizing SERS substrate, comprises substrate of biomass-derived carbon fibers decorated with silver nanoparticles. IN202441102075-A[P]. 2024.

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