| Cocrystal used in pharmaceutical composition for treatment of peptic ulcers and to prevent excess release of gastric acid secretion, comprises lafutidine and conformer selected from iso nicotinamide, piperazine, and glycine | |
| 2024-12-31 | |
| 专利权人 | CHITKARA INNOVATION INCUBATOR FOUND (UCTK-C) ; UNIV CHITKARA (UCTK-C) |
| 申请日期 | 2024-12-31 |
| 专利号 | IN202411105084-A |
| 成果简介 | NOVELTY - Cocrystal comprises lafutidine and conformer selected from an iso nicotinamide, piperazine, and glycine. USE - Cocrystal used in pharmaceutical composition for treatment of peptic ulcers and to prevent excess release of gastric acid secretion. No biological data is given. ADVANTAGE - The cocrystal enhanced the water solubility and subsequently bioavailability; maintaining its efficacy and ascertain it via in- vitro and ex-vivo studies at low dosage; and avoid any potential toxicity. The cocrystal synthesis is carried out at ambient temperatures (higher temperatures are not required) easily scalable and results in product of high purity. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: 1. a method for crystallization of lafutidine, which involves (a) grinding lafutidine with stoichiometric amount of the co-former, with drop wise addition of solvent, and (b) drying the product obtained to obtain cocrystals; and 2. a pharmaceutical composition, which comprises the cocrystal of lafutidine and one or more pharmaceutical carriers or excipients. |
| IPC 分类号 | A61K-045/06 ; A61K-009/14 ; B32B-003/26 ; C07D-401/06 ; C07D-487/04 |
| 国家 | 印度 |
| 专业领域 | 医药卫生 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/13667 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.CHITKARA INNOVATION INCUBATOR FOUND (UCTK-C) 2.UNIV CHITKARA (UCTK-C) |
| 推荐引用方式 GB/T 7714 | DHINGRA N,PRASHAR M,KAUR A,et al. Cocrystal used in pharmaceutical composition for treatment of peptic ulcers and to prevent excess release of gastric acid secretion, comprises lafutidine and conformer selected from iso nicotinamide, piperazine, and glycine. IN202411105084-A[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论