OBTAINING A WATER-SOLUBLE 6-BROMO-1-METHYL-5-METHOXY-2-(1-PIPERIDINOMETHYL)-3-(2-DIETHYLAMINOETHOXY) CARBONYLINDOLE DIHYDROCHLORIDE COMPOUND
	NAROVLYANSKY A N; FILIMONOVA M V; CYSHKOVA N G; PRONIN A V; GREBENNIKOVA T V; KARAMOV E V; LARICHEV V F; KORNILAEVA G V; FEDYAKINA I T; DOLZHIKOVA I V; MEZENTSEVA M V; POLOSKOV V V; KOVAL L S; MARINCHENKO V P; SURINOVA V I; FALIMONOV A S; SHITOVA A A; SOLDATOVA O V; IVANOV S A; SANIN A V; ZUBASHEV I K; VESELOVSKY V V; KOZLOV V V; STEPANOV A V; KHOMICH A V; KOZLOV V S; SHEGAY PY V; KAPRIN A D; ERSHOV F I; GINTSBURG A L
	2022-12-16
专利权人	FEDERAL STATE BUDGETARY INST (FSBI-C)
申请日期	2022-12-16
专利号	RU2835077-C1
成果简介	NOVELTY - Method includes the following synthesis steps: obtaining 1,2-dimethyl-5-methoxy-3-ethoxycarbonylindole from 1,2-dimethyl-5hydroxy-3-ethoxycarbonylindole, then obtaining 6-bromo-1,2-dimethyl-5-methoxy-3-ethoxycarbonylindole from 1,2-dimethyl-5-methoxy-3-ethoxycarbonylindole, then obtaining 6-bromo-2-bromomethyl-1-methyl-5-methoxy-3-ethoxycarbonylindole from 6-bromo-1,2-dimethyl-5-methoxy-3-ethoxycarbonylindole, then obtaining 6-bromo-1-methyl-5-methoxy-2-(1-piperidinomethyl)-3-ethoxycarbonylindole from 6-bromo-2-bromomethyl-1-methyl-5-methoxy-3-ethoxycarbonylindole, then obtaining 6-bromo-1-methyl-5-methoxy-2-(1-piperidinomethyl)indole-3-carboxylic acid hydrochloride from 6-bromo-1-methyl-5-methoxy-2-(1-piperidinomethyl)-3-ethoxycarbonylindole, and obtaining 6-bromo-1-methyl-5-methoxy-2-(1-piperidinomethyl)-3-(2-diethylaminoethoxy)carbonylindole dihydrochloride (compound II). USE - Organic chemistry. ADVANTAGE - Disclosed is a method of producing 6-bromo-1-methyl-5-methoxy-2-(1-piperidinomethyl-3-(2-diethylaminoethoxy)carbonylindole dihydrochloride compound of general formula (II), having high antiviral anti-SARS-CoV-2. 1 cl, 1 dwg, 3 tbl, 14 ex
IPC 分类号	A61K-031/454 ; C07D-403/06
国家	俄罗斯
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/13135
专题	中国科学院新疆生态与地理研究所
作者单位	FEDERAL STATE BUDGETARY INST (FSBI-C)
推荐引用方式 GB/T 7714	NAROVLYANSKY A N,FILIMONOVA M V,CYSHKOVA N G,et al. OBTAINING A WATER-SOLUBLE 6-BROMO-1-METHYL-5-METHOXY-2-(1-PIPERIDINOMETHYL)-3-(2-DIETHYLAMINOETHOXY) CARBONYLINDOLE DIHYDROCHLORIDE COMPOUND. RU2835077-C1[P]. 2022.

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